Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Komagataella Phaffii
SUBMITTER: Jie Luo
LAB HEAD: Jeff Ranish
PROVIDER: PXD011092 | Pride | 2018-10-08
REPOSITORIES: Pride
Chakraborty Manas M Tarasovetc Ekaterina V EV Zaytsev Anatoly V AV Godzi Maxim M Figueiredo Ana C AC Ataullakhanov Fazly I FI Grishchuk Ekaterina L EL
Nature communications 20190411 1
Accurate chromosome segregation relies on microtubule end conversion, the ill-understood ability of kinetochores to transit from lateral microtubule attachment to durable association with dynamic microtubule plus-ends. The molecular requirements for this conversion and the underlying biophysical mechanisms are elusive. We reconstituted end conversion in vitro using two kinetochore components: the plus end-directed kinesin CENP-E and microtubule-binding Ndc80 complex, combined on the surface of a ...[more]