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Identification of dI-binding proteins

ABSTRACT: The dI-binding proteins were enriched and analysed by LC-MS/MS.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Xiaoxia Dai

LAB HEAD: Xiaoxia Dai

PROVIDER: PXD033424 | Pride | 2023-02-03

REPOSITORIES: Pride

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			Action	DRS
	F1dI-0912__forward-1_.raw	Raw
	F2dI-0912__forward-2_.raw	Raw
	RdI-0912__reverse_.raw	Raw
	maxquant-txt.zip	Other

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Publications

Human Mitochondrial Protein HSPD1 Binds to and Regulates the Repair of Deoxyinosine in DNA.

Zheng Xiaofang X Chang Sijia S Liu Yini Y Dai Xiaoxia X You Changjun C

Journal of proteome research 20230228 4

The generation of deoxyinosine (dI) in DNA is one of the most important sources of genetic mutations, which may lead to cancer and other human diseases. A further understanding of the biological consequences of dI necessitates the identification and functional characterizations of dI-binding proteins. Herein, we employed a mass spectrometry-based proteomics approach to detect the cellular proteins that may sense the presence of dI in DNA. Our results demonstrated that human mitochondrial heat sh ...[more]

PMID: 36852893

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