Dataset Information

Impact of graded calorie restriction on mouse liver protein expression

ABSTRACT: Calorie restriction (CR) extends lifespan by modulating the mechanisms involved in aging. We quantified the hepatic proteome of male C57BL/6 mice exposed to graded levels of CR (0% to 40% CR) for three months, and evaluated which signaling pathways were most affected.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Xiahe Huang

LAB HEAD: John Roger Speakman

PROVIDER: PXD033436 | Pride | 2023-10-24

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	121_speakman_run1_F1_20150425_new_ProteinSummary.txt	Txt
	121_speakman_run2_F1_20150427_ProteinSummary.txt	Txt
	121_speakman_run3_F1_20150429_ProteinSummary.txt	Txt
	121_speakman_run4_F1_20150430_ProteinSummary.txt	Txt
	121_speakman_run5_F1_20150505_ProteinSummary.txt	Txt

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Publications

The Effects of Graded Levels of Calorie Restriction: XIX. Impact of Graded Calorie Restriction on Protein Expression in the Liver.

Wang Lu L Derous Davina D Huang Xiahe X Mitchell Sharon E SE Douglas Alex A Lusseau David D Wang Yingchun Y Speakman John R JR

The journals of gerontology. Series A, Biological sciences and medical sciences 20230701 7

Calorie restriction (CR) extends life span by modulating the mechanisms involved in aging. We quantified the hepatic proteome of male C57BL/6 mice exposed to graded levels of CR (0%-40% CR) for 3 months, and evaluated which signaling pathways were most affected. The metabolic pathways most significantly stimulated by the increase in CR, included the glycolysis/gluconeogenesis pathway, the pentose phosphate pathway, the fatty acid degradation pathway, the valine, leucine, and isoleucine degradati ...[more]

PMID: 36757838

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