Dataset Information

SOX4 supports cancer stemness by enhancing HDAC1 transcription revealed by comparative proteomics

ABSTRACT: We have investigated the proteome changes induced by SOX4 overexpression in HCT-116 cells using iTRAQ-based quantitative proteomics. Bioinformatics analysis revealed that HDAC1 could be one of the important regulators in cancer stem cells (CSCs) maintenance. We found that SOX4 transcriptionally regulates HDAC1 to support the stemness of cancer stem cells (CSCs). This work revealed a novel underlying mechanism, SOX4-HDAC1 axis, for stemness maintenance of human cancer.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Lei Zhou

LAB HEAD: Lei Zhou

PROVIDER: PXD019694 | Pride | 2021-09-09

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	HCT116_HpH1_R1_24Nov17.wiff	Wiff
	HCT116_HpH1_R1_24Nov17.wiff.scan	Wiff
	HCT116_HpH1_R2_24Nov17.wiff	Wiff
	HCT116_HpH1_R2_24Nov17.wiff.scan	Wiff
	HCT116_HpH2_R1_24Nov17.wiff	Wiff

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SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study.

Liu Jingshu J Qiu Jiangfeng J Zhang Zhiqi Z Zhou Lei L Li Yunzhe Y Ding Dongyan D Zhang Yang Y Zou Dongling D Wang Dong D Zhou Qi Q Lang Tingyuan T

Cell & bioscience 20210122 1

<h4>Background</h4>Cancer stem cells (CSCs) are the root of human cancer development and the major cause of treatment failure. Aberrant elevation of SOX4, a member of SOX (SRY-related HMG-box) family transcription factors, has been identified in many types of human cancer and promotes cancer development. However, the role of SOX4 in CSCs, especially at a proteome-wide level, has remained elusive. The aim of this study is to investigate the effect of SOX4 on the stemness of CSCs and reveal the un ...[more]

PMID: 33482915

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