Proteomics

Dataset Information

0

Drosophila variant Polycomb complex subunits LC-MS


ABSTRACT: Our proteomics anaylsis in Drosophila embryos revealed alternative forms of PRC2 and several distinct variant PRC1 types which are similar to polycomb complexes in mammals

INSTRUMENT(S): LTQ Orbitrap Velos Pro, Orbitrap Exploris 480, LTQ Orbitrap Elite

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Embryo, Late Embryo

SUBMITTER: Hyuckjoon Kang  

LAB HEAD: Mitzi I. Kuroda

PROVIDER: PXD033615 | Pride | 2022-10-15

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
549255_KDM2_BioTAP.mzid.gz Mzid
549256_KDM2_Input.mzid.gz Mzid
549257_Pcl_BioTAP.mzid.gz Mzid
549258_PRC2_Input.mzid.gz Mzid
549259_RYBP_BioTAP.mzid.gz Mzid
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Publications

Variant Polycomb complexes in <i>Drosophila</i> consistent with ancient functional diversity.

Kang Hyuckjoon H   Cabrera Janel R JR   Zee Barry M BM   Kang Heather A HA   Jobe Jenny Marie JM   Hegarty Maeve B MB   Barry Aurelie E AE   Glotov Alexander A   Schwartz Yuri B YB   Kuroda Mitzi I MI  

Science advances 20220907 36


Polycomb group (PcG) mutants were first identified in <i>Drosophila</i> on the basis of their failure to maintain proper <i>Hox</i> gene repression during development. The proteins encoded by the corresponding fly genes mainly assemble into one of two discrete Polycomb repressive complexes: PRC1 or PRC2. However, biochemical analyses in mammals have revealed alternative forms of PRC2 and multiple distinct types of noncanonical or variant PRC1. Through a series of proteomic analyses, we identify  ...[more]

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