Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: Uwe Warnken
LAB HEAD: Uwe Warnken
PROVIDER: PXD033760 | Pride | 2023-10-24
REPOSITORIES: Pride
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Coppola Valeria V Marino Ilaria I Warnken Uwe U Falchi Mario M Pasquini Luca L Biffoni Mauro M De Maria Ruggero R Haas Tobias Longin TL
Autophagy 20230707 10
Apoptosis is a tightly controlled cell death program executed by proteases, the so-called caspases. It plays an important role in tissue homeostasis and is often dysregulated in cancer. Here, we identified FYCO1, a protein that promotes microtubule plus end-directed transport of autophagic and endosomal vesicles as a molecular interaction partner of activated CASP8 (caspase 8). The absence of FYCO1 sensitized cells to basal and TNFSF10/TRAIL-induced apoptosis by receptor accumulation and stabili ...[more]