Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Johannes Fuchs
LAB HEAD: Lars Palmqvist
PROVIDER: PXD034416 | Pride | 2024-09-30
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
QEHF_190827_05.msf | Msf | |||
QEHF_190827_05.raw | Raw | |||
QEHF_190827_08.msf | Msf | |||
QEHF_190827_08.raw | Raw | |||
QEHF_190827_11.msf | Msf |
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Haematologica 20240301 3
Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome, such as AML with translocation t(7;12)(q36;p13) leading to an MNX1::ETV6 fusion along with high expression of MNX1. We have identified the transforming event in this AML and possible ways of treatment. Retroviral expression of MNX1 was able to induce AML in mice, with similar gene expression and pathway enrichment to t(7;12) AML patient data. Importantly, this leukemia was only induced in immune incompetent mice ...[more]