Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Stem Cell, Bone Marrow
SUBMITTER: Ashokkumar Jayavelu
LAB HEAD: Prof.Matthias Mann
PROVIDER: PXD028007 | Pride | 2022-03-08
REPOSITORIES: pride
Items per page: 1 - 5 of 15 |
Cancer cell 20220303 3
Acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis. We report a comprehensive proteogenomic analysis of bone marrow biopsies from 252 uniformly treated AML patients to elucidate the molecular pathophysiology of AML in order to inform future diagnostic and therapeutic approaches. In addition to in-depth quantitative proteomics, our analysis includes cytogenetic profiling and DNA/RNA sequencing. We identify five proteomic AML subtypes, each reflecting specific biologi ...[more]