Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Cell Culture
SUBMITTER: Mehari Weldemariam
LAB HEAD: Qibin Zhang
PROVIDER: PXD034608 | Pride | 2024-01-26
REPOSITORIES: Pride
Items per page: 1 - 5 of 49 |
Proteomics 20230724 19
Pancreatic β-cell dysfunction is an early hallmark of type 1 diabetes mellitus. Among the potentially critical factors that cause β-cell dysfunction are cytokine attack, glucotoxicity, induction of endoplasmic reticulum (ER) or mitochondria stress. However, the exact molecular mechanism underlying β-cell's inability to maintain glucose homeostasis under severe stresses is unknown. This study used proinflammatory cytokines, thapsigargin, and rotenone in the presence of high concentration glucose ...[more]