Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Viral Pneumonia
SUBMITTER: Yingxin Zhao
LAB HEAD: Yingxin Zhao
PROVIDER: PXD034780 | Pride | 2022-10-14
REPOSITORIES: Pride
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Zhao Yingxin Y Qiao Dianhua D Skibba Melissa M Brasier Allan R AR
International journal of molecular sciences 20220812 16
Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections (LRTI) associated with decreased pulmonary function, asthma, and allergy. Recently, we demonstrated that RSV induces the hexosamine biosynthetic pathway via the unfolded protein response (UPR), which is a pathway controlling protein glycosylation and secretion of the extracellular matrix (ECM). Because the presence of matrix metalloproteinases and matricellular growth factors (TGF) is associated with severe LRTI, ...[more]