Proteomics

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ACP Acylation Is an Acetyl-CoADependent Modification Required for Electron Transport Chain Assembly


ABSTRACT: The electron transport chain (ETC) is an important participant in cellular energy conversion, but its biogenesis presents the cell with numerous challenges. To address these complexities, the cell utilizes ETC assembly factors, which include the LYR protein family. Each member of this family interacts with the mitochondrial acyl carrier protein (ACP), the scaffold protein upon which the mitochondrial fatty acid synthesis (mtFAS) pathway builds fatty acyl chains from acetyl-CoA. We demonstrate that the acylated form of ACP is an acetyl-CoA-dependent allosteric activator of the LYR protein family used to stimulate ETC biogenesis. By tuning ETC assembly to the abundance of acetyl-CoA, which is the major fuel of the TCA cycle and ETC, this system could provide an elegant mechanism for coordinating the assembly of ETC complexes with one another and with substrate availability.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Jonathan Van Vranken  

LAB HEAD: Jared Rutter

PROVIDER: PXD035000 | Pride | 2022-07-11

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
yeast_wc_10_c03356.mzIdentML Mzid
yeast_wc_10_c03356.raw Raw
yeast_wc_11_c03357.mzIdentML Mzid
yeast_wc_11_c03357.raw Raw
yeast_wc_12_c03358.mzIdentML Mzid
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