Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

RNA-sequencing analysis of glucose and acetate regulated transcripts in glioblastoma cells

ABSTRACT: Our studies indicate that glucose and acetate can regulate histone acetylation by altering the acetyl-CoA concentrations in the cell. The purpose of this study was to to determine whether specific gene sets correlated with acetyl-CoA availability. We conclude that 10% of glucose-regulated genes are acetyl-CoA regulated genes (genes suppressed or induced by low glucose and reversed by acetate). Acetate usually regulated gene expression in the same direction as glucose, suggesting that acetyl-CoA is a key mediator of glucose-dependent gene expression. The experiments were performed in quadruplicates for each condition with a total of 12 samples

ORGANISM(S): Homo sapiens

SUBMITTER: Kathryn Wellen 

PROVIDER: E-GEOD-57488 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Histone acetylation plays important roles in gene regulation, DNA replication, and the response to DNA damage, and it is frequently deregulated in tumors. We postulated that tumor cell histone acetylation levels are determined in part by changes in acetyl coenzyme A (acetyl-CoA) availability mediated by oncogenic metabolic reprogramming. Here, we demonstrate that acetyl-CoA is dynamically regulated by glucose availability in cancer cells and that the ratio of acetyl-CoA:coenzyme A within the nuc  ...[more]

Similar Datasets

Transcriptomics RNA-sequencing analysis of glucose and acetate regulated transcripts in glioblastoma cells
2014-08-05 | GSE57488 | GEO
Genomics ACSS2 and ACLY link nutrient-dependent chromatin accessibility to regulation of CD8 T cell effector responses
2024-08-01 | GSE262865 | GEO
Transcriptomics ACLY and ACSS2 link nutrient-dependent chromatin accessibility to regulation of CD8 T cell effector responses [RNA-seq]
2024-07-04 | GSE270851 | GEO
Transcriptomics ACLY and ACSS2 link nutrient-dependent chromatin accessibility to regulation of CD8 T cell effector responses
2024-07-04 | GSE267377 | GEO
Transcriptomics Transcriptome analysis of C. glutamicum ΔaceE Δpyc versus ΔaceE
2019-07-31 | GSE134218 | GEO
Transcriptomics Acetate is a driver of quiescence in ovarian cancer
2024-10-16 | GSE271035 | GEO
Transcriptomics Acetate promotes T cell effector function during glucose restriction [RNA-seq]
2019-05-14 | GSE128591 | GEO
Genomics Acetate promotes T cell effector function during glucose restriction [ChIP-seq]
2019-05-14 | GSE128593 | GEO
Genomics Acetate promotes T cell effector function during glucose restriction [ATAC-seq]
2019-05-14 | GSE128592 | GEO
Transcriptomics Generation of Escherichia coli Enhanced Acetate Utilization through Compensatory ATP Consumption via Adaptive Laboratory Evolution
2020-09-15 | GSE157942 | GEO