Proteomics

Dataset Information

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Interactome of ferroptosis pathways genes


ABSTRACT: We conducted a proteomic interactome analysis of well-known regulators of ferroptosis, ACSL4, LPCAT3, ALOX12, ALOX15, PEBP1, NCOA4, GCH1, FSP1, DHODH, SLC7A11, GCLC, GCLM, GSS, and GPX4. Take LPCAT3 as an example, we uncovered an opposing role of its binding protein CEPT1 in suppressing ferroptosis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Zhen Chen  

LAB HEAD: Junjie Chen

PROVIDER: PXD035146 | Pride | 2024-10-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
03012020_XG_FSP1_1.msf Msf
03012020_XG_FSP1_1.raw Raw
03012020_XG_FSP1_2.msf Msf
03012020_XG_FSP1_2.raw Raw
08212018_ACSL4_1.msf Msf
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Publications


Ferroptosis has been recognized as a unique cell death modality driven by excessive lipid peroxidation and unbalanced cellular metabolism. In this study, we established a protein interaction landscape for ferroptosis pathways through proteomic analyses, and identified choline/ethanolamine phosphotransferase 1 (CEPT1) as a lysophosphatidylcholine acyltransferase 3 (LPCAT3)-interacting protein that regulates LPCAT3 protein stability. In contrast to its known role in promoting phospholipid synthesi  ...[more]

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