Proteomics

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Plasmodium falciparum Chr3C7 and Chr3C16 DiQ-BioID data

ABSTRACT: As part of a larger study characterizing all unknown 'nonsecretory' proteins encoded on chromosome 3 of P. falciparum parasites, we selected two candidate proteins (Chr3C7 and Chr3C16) to obtain interactomes using dimerisation-induced quantitative BioID (DiQ-BioID). This set of experiments resulted in a list of significantly enriched proteins which identified interactors and compartment neighbours of the selected proteins.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

SUBMITTER: Gala Ramon-Zamorano  

LAB HEAD: Tobias Spielmann

PROVIDER: PXD035332 | Pride | 2023-02-17

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20190708_Fusion1_SA_CT_TSext_R_setD_FW.raw Raw
20190708_Fusion1_SA_CT_TSext_R_setE_REV.raw Raw
20210827_Exploris1_SA_PJ_TSext_pf_A_M7C_BioID_dimethyl_Forward.raw Raw
20210827_Exploris1_SA_PJ_TSext_pf_B_M7C_BioID_dimethyl_Reverse.raw Raw
20210827_Exploris1_SA_PJ_TSext_pf_C_M7N_BioID_dimethyl_Forward.raw Raw
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Publications

Taxon-specific proteins are key determinants defining the biology of all organisms and represent prime drug targets in pathogens. However, lacking comparability with proteins in other lineages makes them particularly difficult to study. In malaria parasites, this is exacerbated by technical limitations. Here, we analyzed the cellular location, essentiality, function, and, in selected cases, interactome of all unknown non-secretory proteins encoded on an entire P. falciparum chromosome. The nucle  ...[more]

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