Proteomics

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Mouse muscle spindle proteomics

ABSTRACT: The proprioceptive system is essential for the control of coordinated movement, posture and skeletal integrity. The sense of proprioception is produced in the brain using peripheral sensory input from receptors such as the muscle spindle, which detects changes in the length of skeletal muscles. Despite its importance, the molecular composition of the muscle spindle is largely unknown. In this study, we generated comprehensive transcriptomic and proteomic datasets of the entire muscle spindle. We then associated differentially expressed genes with the various tissues composing the spindle using bioinformatic analysis. Immunostaining verified these predictions, thus establishing new markers for the different spindle tissues. Utilizing these markers, we identified the differentiation stages the spindle capsule cells undergo during development. Together, these findings provide comprehensive molecular characterization of the intact spindle as well as new tools to study its development and function in health and disease.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Alon Savidor  

LAB HEAD: Prof. Elazar Zelzer

PROVIDER: PXD035552 | Pride | 2023-02-17

REPOSITORIES: Pride

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Dataset's files

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Action DRS
HFX_7547_EZE_M1_muscle_130618.raw Raw
HFX_7547_EZE_M1_nerve_130618.raw Raw
HFX_7547_EZE_M1_spindle_130618.raw Raw
HFX_7547_EZE_M2_muscle_130618.raw Raw
HFX_7547_EZE_M2_nerve_130618.raw Raw
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Publications

Molecular characterization of the intact mouse muscle spindle using a multi-omics approach.

Bornstein Bavat B   Heinemann-Yerushalmi Lia L   Krief Sharon S   Adler Ruth R   Dassa Bareket B   Leshkowitz Dena D   Kim Minchul M   Bewick Guy G   Banks Robert W RW   Zelzer Elazar E  

eLife 20230206

The proprioceptive system is essential for the control of coordinated movement, posture, and skeletal integrity. The sense of proprioception is produced in the brain using peripheral sensory input from receptors such as the muscle spindle, which detects changes in the length of skeletal muscles. Despite its importance, the molecular composition of the muscle spindle is largely unknown. In this study, we generated comprehensive transcriptomic and proteomic datasets of the entire muscle spindle is  ...[more]

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