Proteomics

Dataset Information

0

Chemical Targeting of the Redox Switch in the Transcription Factor ΔFOSB

ABSTRACT: Purified protein fragments (~8 kDa bZIP domains, ΔFOSB and JunD) were reacted with individual compounds selected from a previous library screen. Reacted proteins were analyzed by LC-MS/MS peptide mapping and LC-MS intact mass analysis.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Mixed Disorder As Reaction To Stress

SUBMITTER: Aaron Bailey  

LAB HEAD: Gabrielle Rudenko

PROVIDER: PXD035839 | Pride | 2022-10-14

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
11142019_mono_GRGA_51.raw Raw
GA56_200ng2uL_SEC200_s40m_ot120ot240_HCD30-ipa3PTR10_111820_220.raw Raw
GA57_200ng2uL_SEC200_s40m_ot120ot240_HCD30-ipa3PTR10_111820_223.raw Raw
GA58_200ng2uL_SEC200_s40m_ot120ot240_HCD30-ipa3PTR10_111820_226.raw Raw
GA66_E_pepmap_tryp_020621.xlsx Xlsx
Items per page:
1 - 5 of 11
altmetric image

Publications

The AP1 transcription factor ΔFOSB, a splice variant of FOSB, accumulates in the brain in response to chronic insults such as exposure to drugs of abuse, depression, Alzheimer's disease and tardive dyskinesias, and mediates subsequent long-term neuroadaptations. ΔFOSB forms heterodimers with other AP1 transcription factors, e.g. JUND, that bind DNA under control of a putative cysteine-based redox switch. Here, we reveal the structural basis of the redox switch by determining a key missing crysta  ...[more]

Similar Datasets

Genomics Proteomics_LC-MS_MS
| EGAD00010001006 | EGA
Genomics Mus musculus
| PRJNA811808 | ENA
Proteomics Profiling of a high mannose-type N-glycosylated lipase using hydrophilic interaction chromatography-mass spectrometry
2020-05-04 | PXD016215 | Pride
Proteomics Rapid Highly-Efficient Digestion and Peptide Mapping of Adeno-Associated Viruses
2022-02-17 | PXD025971 | Pride
Proteomics Dilute-and-Shoot Analysis of Therapeutic Monoclonal Antibody Variants in Fermentation Broth: A Method Capability Study
2019-11-12 | PXD011017 | Pride
Other Identification of targets of the protein disulfide reductase thioredoxin
2008-11-20 | GSE11650 | GEO
Proteomics Development of an in vitro screening system for synthetic signal peptide in mammalian cell-based protein production.
2022-05-24 | PXD033441 | Pride
Transcriptomics Metagenomic, metatranscriptomic and metaproteomic study of enrichment culture of M. oxyfera (denitrifying methanotroph)
2010-03-25 | GSE18535 | GEO
Transcriptomics Correlation Analysis of Expression Profile and Quantitative iTRAQ-LC-MS/MS Proteomics Reveals Resistance Mechanism Against TuMV in Chinese Cabbage (Brassica rapa ssp. pekinensis)
2020-08-07 | GSE151932 | GEO
Proteomics Characterization of human sperm protamine proteoforms through a combination of top-down and bottom-up mass spectrometry approaches
2019-11-11 | PXD014618 | Pride