Dataset Information
Chemical Targeting of the Redox Switch in the Transcription Factor ΔFOSB
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Mixed Disorder As Reaction To Stress
SUBMITTER: 
Aaron Bailey
LAB HEAD: Gabrielle Rudenko
PROVIDER: PXD035839 | Pride | 2022-10-14
REPOSITORIES: Pride
Dataset's files
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Publications
Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.
Nucleic acids research 20220901 16
The AP1 transcription factor ΔFOSB, a splice variant of FOSB, accumulates in the brain in response to chronic insults such as exposure to drugs of abuse, depression, Alzheimer's disease and tardive dyskinesias, and mediates subsequent long-term neuroadaptations. ΔFOSB forms heterodimers with other AP1 transcription factors, e.g. JUND, that bind DNA under control of a putative cysteine-based redox switch. Here, we reveal the structural basis of the redox switch by determining a key missing crysta ...[more]
