Dataset Information

Wnt/β-catenin and NFκB signaling synergize to trigger growth-factor-free regeneration of adult primary human hepatocytes

ABSTRACT: The liver has a remarkable capacity to regenerate, which is sustained by the ability of hepatocytes to act as facultative stem cells that, while normally quiescent, re-enter the cell cycle upon injury. In rodents, growth factor signaling is indispensable, whereas Wnt/β-catenin is not required for effective tissue repair. However, molecular networks controlling human liver regeneration remain unclear.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

SUBMITTER: Christian Beusch

LAB HEAD: Volker M. Lauschke

PROVIDER: PXD036100 | Pride | 2024-05-22

REPOSITORIES: Pride

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Wnt/β-catenin and NFκB signaling synergize to trigger growth factor-free regeneration of adult primary human hepatocytes.

Oliva-Vilarnau Nuria N Beusch Christian M CM Sabatier Pierre P Sakaraki Eirini E Tjaden Amelie A Graetz Lukas L Büttner Florian A FA Dorotea Debra D Nguyen My M Bergqvist Filip F Sundström Yvonne Y Müller Susanne S Zubarev Roman A RA Schulte Gunnar G Tredup Claudia C Gramignoli Roberto R Tietge Uwe J F UJF Lauschke Volker M VM

Hepatology (Baltimore, Md.) 20231023 6

<h4>Background and aims</h4>The liver has a remarkable capacity to regenerate, which is sustained by the ability of hepatocytes to act as facultative stem cells that, while normally quiescent, re-enter the cell cycle after injury. Growth factor signaling is indispensable in rodents, whereas Wnt/β-catenin is not required for effective tissue repair. However, the molecular networks that control human liver regeneration remain unclear.<h4>Methods</h4>Organotypic 3D spheroid cultures of primary huma ...[more]

PMID: 37870288

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