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Flycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 1/6

ABSTRACT: During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide barcodes, called flycodes, allows for the simultaneous preclinical assessment of dozens of antibodies from single cassette-dosed mice. Datasets: 1. comparison of flycodes vs. unique endogenous tryptic peptides for antibody identification 2. antibody PK, cassette dose A (high dose) 3. antibody PK, cassette dose B (low dose) 4. antibody tumor/organ biodistribution 5. Dar-SB thermostability 6. Dar-SB PK

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Justin Walter

LAB HEAD: Markus Seeger

PROVIDER: PXD036658 | Pride | 2025-02-26

REPOSITORIES: pride

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			Action	DRS
	20210928_014_S317806_12ug-mAbs_tryp_A.raw	Raw
	20210928_015_S317807_4ug-mAbs_tryp_A.raw	Raw
	20210928_endogenous-vs-flycode_mascot-search.dat	Other
	20210928_export4mascot_rank5ions1000.mgf	Mgf
	fgcz_swissprot_d_20140403.fasta	Fasta

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