Proteomics

Dataset Information

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Staphylococcal Nuclease and Tudor Domain Containing protein SND1 interacts with ERG and plays a critical role in prostate cancer in vivo


ABSTRACT: ERG is a transcriptional factor, which is recombined with promoter of TMPRSS2 and prominently overexpressed in half of human prostate cancers. The mechanisms of ERG-mediated oncogenesis are not completely understood. We performed an unbiased Mass Spectrometry screen for ERG-binding proteins and found that ERG binds to MTDH/SND1 protein complex in prostate cancer cells. We determined that ERG binds to the SND1/MTDH protein complex via SND1 and this interaction plays a critical role in ERG-mediated cancer.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Sadhna Phanse  

LAB HEAD: Andrew Emili

PROVIDER: PXD036882 | Pride | 2023-03-22

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20201020_HomoSapiens.fasta Fasta
JK_20120804_03_vaGFP_VCAP.mzXML Mzxml
JK_20120804_11_ERGva_OK.mzXML Mzxml
JK_20120804_17_vaERG_OK.mzXML Mzxml
andromeda.tar.gz Other
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Publications

Staphylococcal Nuclease and Tudor Domain Containing 1 (SND1 Protein) Promotes Hepatocarcinogenesis by Inhibiting Monoglyceride Lipase (MGLL).

Rajasekaran Devaraja D   Jariwala Nidhi N   Mendoza Rachel G RG   Robertson Chadia L CL   Akiel Maaged A MA   Dozmorov Mikhail M   Fisher Paul B PB   Sarkar Devanand D  

The Journal of biological chemistry 20160320 20


Staphylococcal nuclease and tudor domain containing 1 (SND1) is overexpressed in multiple cancers, including hepatocellular carcinoma (HCC), and functions as an oncogene. This study was carried out to identify novel SND1-interacting proteins to better understand its molecular mechanism of action. SND1-interacting proteins were identified by a modified yeast two-hybrid assay. Protein-protein interaction was confirmed by co-immunoprecipitation analysis. Monoglyceride lipase (MGLL) expression was a  ...[more]

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