Lung Cancer Drug resistance LC-MS/MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung
SUBMITTER: 
Esen Efeoglu
LAB HEAD: Paula Meleady
PROVIDER: PXD036996 | Pride | 2023-03-10
REPOSITORIES: Pride
Publications
Label-Free Quantitative Proteomics Analysis of Adriamycin Selected Multidrug Resistant Human Lung Cancer Cells.
Efeoglu Esen E Henry Michael M Clynes Martin M Meleady Paula P
Biomolecules 20221001 10
The development of drug resistance in lung cancer is a major clinical challenge, leading to a 5-year survival rate of only 18%. Therefore, unravelling the mechanisms of drug resistance and developing novel therapeutic strategies is of crucial importance. This study systematically explores the novel biomarkers of drug resistance using a lung cancer model (DLKP) with a series of drug-resistant variants. In-depth label-free quantitative mass spectrometry-based proteomics and gene ontology analysis ...[more]
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