Proteomics

Dataset Information

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Isolation and Characterization of ZK002, A Novel Dual Function Snake Venom Peptide from Deinagkistrodon acutus with Anti-angiogenic and Anti-inflammatory Properties


ABSTRACT: Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence supports the close linkage between angiogenesis and inflammation. Snake venoms are a rich natural source of biologically active molecules and carry rich potential for the discovery anti-angiogenic and anti-inflammatory modulators. Here, we isolated and purified a novel protein, ZK002, from the venom of the snake Deinagkistrodon acutus, and investigated its anti-angiogenic and anti-inflammatory activities and mechanisms.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Deinagkistrodon Acutus

TISSUE(S): Venom

SUBMITTER: William Chi-Shing Tai  

LAB HEAD: William Chi-Shing Tai

PROVIDER: PXD037093 | Pride | 2023-10-24

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
ZK5.mgf Mgf
ZK57_100X_1ul.raw Raw
checksum.txt Txt
zk002.mzid.gz Mzid
zkproject_mascot.dat Other
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Publications

Isolation and characterization of ZK002, a novel dual function snake venom protein from <i>Deinagkistrodon acutus</i> with anti-angiogenic and anti-inflammatory properties.

Chan Brandon Dow BD   Wong Wing-Yan WY   Lee Magnolia Muk-Lan MM   Yue Patrick Ying-Kit PY   Dai Xiangrong X   Tsim Karl Wah-Keung KW   Hsiao Wen-Luan Wendy WW   Li Mandy M   Li Xiao-Yi XY   Tai William Chi-Shing WC  

Frontiers in pharmacology 20230929


<b>Introduction:</b> Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence supports the close linkage between angiogenesis and inflammation. Snake venoms are a rich natural source of biologically active molecules and carry rich potential for the discovery of anti-angiogenic and anti-inflammatory modulators. <b>Methods:</b> Here,  ...[more]

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