Dataset Information

Human Prostate Cancer epithelial-fibroblast cell signalling by CTAP-MS

ABSTRACT: A greater understanding of cell signaling events that occur within the prostate cancer tumor microenvironment (TME), for example between cancer-associated fibroblasts (CAFs) and prostate epithelial or cancer cells, may identify novel biomarkers and more effective therapeutic strategies for this disease. To address this, we used cell-type specific labelling with amino acid precursors (CTAP) to define cell type-specific phosphoproteomic changes that occur when prostate epithelial cells are co-cultured with normal patient-derived prostate fibroblasts (NPFs) versus matched CAFs.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Testis, Epithelial Cell

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Terry Lim

LAB HEAD: Roger Daly

PROVIDER: PXD037272 | Pride | 2023-03-11

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20200614_CTAP_P332_TiO2_R1.raw	Raw
	20200614_CTAP_P332_TiO2_R2.raw	Raw
	20200614_CTAP_P332_TiO2_R3.raw	Raw
	20200614_CTAP_P332_WP_R1.raw	Raw
	20200614_CTAP_P332_WP_R2.raw	Raw

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Publications

Cell-Type-Specific Signalling Networks Impacted by Prostate Epithelial-Stromal Intercellular Communication.

Clark Kimberley C KC Nguyen Elizabeth V EV Niranjan Birunthi B Wu Yunjian Y Lim Kam Sian Terry C C TCC Horvath Lisa G LG Taylor Renea A RA Daly Roger J RJ

Cancers 20230123 3

Prostate cancer is the second most common cause of cancer death in males. A greater understanding of cell signalling events that occur within the prostate cancer tumour microenvironment (TME), for example, between cancer-associated fibroblasts (CAFs) and prostate epithelial or cancer cells, may identify novel biomarkers and more effective therapeutic strategies for this disease. To address this, we used cell-type-specific labelling with amino acid precursors (CTAP) to define cell-type-specific ( ...[more]

PMID: 36765657

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