Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Streptomyces Filamentosus Nrrl 15998
TISSUE(S): Mycelium
SUBMITTER: weifeng xu
LAB HEAD: Weifeng Xu
PROVIDER: PXD037377 | Pride | 2024-05-23
REPOSITORIES: Pride
Action | DRS | |||
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S9764GI_sample1.raw | Raw | |||
S9764GI_sample2.raw | Raw | |||
S9764GI_sample3.raw | Raw | |||
SD278GP_atra.raw | Raw | |||
VA025GI_prcB_A.raw | Raw |
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Protein science : a publication of the Protein Society 20230401 4
The efficiency of drug biosynthesis depends on different transcriptional regulatory pathways in Streptomyces, and the protein degradation system adds another layer of complexity to the regulatory processes. AtrA, a transcriptional regulator in the A-factor regulatory cascade, stimulates the production of daptomycin by binding to the dptE promoter in Streptomyces roseosporus. Using pull-down assays, bacterial two-hybrid system and knockout verification, we demonstrated that AtrA is a substrate fo ...[more]