Dataset Information

Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile for multiple solid tumors

ABSTRACT: Mass spectrometry raw data for submitting manuscript entitled "Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile for multiple solid tumors" to Nature Communications.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Yuan LIN

LAB HEAD: Lin Yuan

PROVIDER: PXD037429 | Pride | 2023-05-22

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	R20180200167_NS3M_FLAG.msf	Msf
	R20180200167_NS3M_FLAG.raw	Raw
	R20180200167_NS3M_IGG.msf	Msf
	R20180200167_NS3M_IGG.raw	Raw
	R20180200167_NS3_FLAG.msf	Msf

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Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile.

Guo Li L Hu Cheng C Liu Yang Y Chen Xiaoyu X Song Deli D Shen Runling R Liu Zhanzhen Z Jia Xudong X Zhang Qinfen Q Gao Yuanzhu Y Deng Zhezhi Z Zuo Tao T Hu Jun J Zhu Wenbo W Cai Jing J Yan Guangmei G Liang Jiankai J Lin Yuan Y

Nature communications 20230609 1

Oncolytic viruses (OVs) represent a type of encouraging multi-mechanistic drug for the treatment of cancer. However, attenuation of virulence, which is generally required for the development of OVs based on pathogenic viral backbones, is frequently accompanied by a compromised killing effect on tumor cells. By exploiting the property of viruses to evolve and adapt in cancer cells, we perform directed natural evolution on refractory colorectal cancer cell HCT-116 and generate a next-generation on ...[more]

PMID: 37296165

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