Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Neuroblastoma
SUBMITTER: Dennis Kappei
LAB HEAD: Dennis Kappei
PROVIDER: PXD037670 | Pride | 2023-12-08
REPOSITORIES: Pride
Action | DRS | |||
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20201011_QPC_DK_CSI_TS_WL_GIMEN_ASCL1_IP.zip | Other | |||
20201011_QPC_DK_CSI_TS_WL_GIMEN_ASCL1_IP_for.raw | Raw | |||
20201011_QPC_DK_CSI_TS_WL_GIMEN_ASCL1_IP_rev.raw | Raw |
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Wang Lu L Tan Tze King TK Kim Hyoju H Kappei Dennis D Tan Shi Hao SH Look A Thomas AT Sanda Takaomi T
Cell reports 20231205 12
Neuroblastoma originates from developing neural crest and can interconvert between the mesenchymal (MES) and adrenergic (ADRN) states, each of which are controlled by different sets of transcription factors forming the core regulatory circuit (CRC). However, the roles of CRC factors in induction and maintenance of specific state are poorly understood. Here, we demonstrate that overexpression of ASCL1, an ADRN CRC factor, in MES neuroblastoma cells opens closed chromatin at the promoters of key A ...[more]