Dataset Information

The brain protein secreted amyloid precursor protein alpha (sAPPalpha) regulates neurologically-important proteins of the cellular proteome and secretome of mouse primary astrocytes

ABSTRACT: Mouse primary astrocytes in culture were exposed to 1 nM secreted amyloid precursor protein alpha (sAPPalpha) or PBS (control) for 2 h or 6 h and changes in the cellular proteome or secretome respectively were quantified by SWATH-MS.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Astrocyte Of The Cerebral Cortex

DISEASE(S): Disease Free

SUBMITTER: Torsten Kleffmann

LAB HEAD: Warren Perry Tate

PROVIDER: PXD037902 | Pride | 2023-05-10

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	19045_Proteome_DDA_IEF_A_Fr1.wiff	Wiff
	19045_Proteome_DDA_IEF_A_Fr1.wiff.scan	Wiff
	19045_Proteome_DDA_IEF_A_Fr10.wiff	Wiff
	19045_Proteome_DDA_IEF_A_Fr10.wiff.scan	Wiff
	19045_Proteome_DDA_IEF_A_Fr11.wiff	Wiff

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Publications

Secreted Amyloid Precursor Protein Alpha (sAPPα) Regulates the Cellular Proteome and Secretome of Mouse Primary Astrocytes.

Peppercorn Katie K Kleffmann Torsten T Hughes Stephanie M SM Tate Warren P WP

International journal of molecular sciences 20230412 8

Secreted amyloid precursor protein alpha (sAPPα), processed from a parent mammalian brain protein, amyloid precursor protein, can modulate learning and memory. Recently it has been shown to modulate the transcriptome and proteome of human neurons, including proteins with neurological functions. Here, we analysed whether the acute administration of sAPPα facilitated changes in the proteome and secretome of mouse primary astrocytes in culture. Astrocytes contribute to the neuronal processes of neu ...[more]

PMID: 37108327

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