Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Testis
SUBMITTER: 
Antrix Jain
LAB HEAD: Martin M. Matzuk
PROVIDER: PXD038012 | Pride | 2023-11-21
REPOSITORIES: Pride
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Publications
Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.
Nozawa Kaori K Garcia Thomas X TX Kent Katarzyna K Leng Mei M Jain Antrix A Malovannaya Anna A Yuan Fei F Yu Zhifeng Z Ikawa Masahito M Matzuk Martin M MM
Andrology 20221116 5
<h4>Background</h4>The importance of phosphorylation in sperm during spermatogenesis has not been pursued extensively. Testis-specific serine kinase 3 (Tssk3) is a conserved gene, but TSSK3 kinase functions and phosphorylation substrates of TSSK3 are not known.<h4>Objective</h4>The goals of our studies were to understand the mechanism of action of TSSK3.<h4>Materials and methods</h4>We analyzed the localization of TSSK3 in sperm, used CRISPR/Cas9 to generate Tssk3 knockout (KO) mice in which nea ...[more]
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