Dataset Information

Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells

ABSTRACT: Hormone dependent breast cancer (HDBC) is the most commonly diagnosed tumor type in women. Adjuvant endocrine therapies (ET) have been the cornerstone in the clinical management of HDBC patients for over forty years. A vast proportion of HDBC patients incur long periods of clinical dormancy following ET, with tumour awakening appearing at a steady pace for up to 25 years (Pan et al., 2017). Extensive genomic studies have demonstrated that 15-30% of clinical relapses develop recurrent genomic changes which contribute to drug resistance (i.e. ESR1 activating mutations) (Bertucci et al., 2019; Magnani et al., 2017; Razavi et al., 2018). However, even in these cases, there is no conclusive evidence around the pre-existence vs. de novo nature of these events. Here, we analyzed histone PTMs in dormant and awakened breast cancer cells treated with endocrine therapy.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Breast Cancer

SUBMITTER: Roberta Noberini

LAB HEAD: Tiziana Bonaldi

PROVIDER: PXD038030 | Pride | 2024-05-23

REPOSITORIES: Pride

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			Action	DRS
	HF220914_RN_Magnani_1.raw	Raw
	HF220914_RN_Magnani_10.raw	Raw
	HF220914_RN_Magnani_12.raw	Raw
	HF220914_RN_Magnani_15.raw	Raw
	HF220914_RN_Magnani_19.raw	Raw

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Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells.

Rosano Dalia D Sofyali Emre E Dhiman Heena H Ghirardi Chiara C Ivanoiu Diana D Heide Timon T Vingiani Andrea A Bertolotti Alessia A Pruneri Giancarlo G Canale Eleonora E Dewhurst Hannah F HF Saha Debjani D Slaven Neil N Barozzi Iros I Li Tong T Zemlyanskiy Grigory G Phillips Henry H James Chela C Győrffy Balázs B Lynn Claire C Cresswell George D GD Rehman Farah F Noberini Roberta R Bonaldi Tiziana T Sottoriva Andrea A Magnani Luca L

Cancer discovery 20240501 5

Patients with estrogen receptor-positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients relapse even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic and transcriptional changes underlying tumor awakening, we analyzed late relapse patients and longitudinally profiled a rare cohort treated with long-term neoadjuvant ETs until progr ...[more]

PMID: 38527495

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