Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain, Hippocampus
DISEASE(S): Epilepsy
SUBMITTER: Mark Graham
LAB HEAD: Mark Evan Graham
PROVIDER: PXD038241 | Pride | 2024-02-22
REPOSITORIES: Pride
Hurtado Silva Mariella M van Waardenberg Ashley J AJ Mostafa Aya A Schoch Susanne S Dietrich Dirk D Graham Mark E ME
iScience 20240319 4
To investigate the phosphorylation-based signaling and protein changes occurring early in epileptogenesis, the hippocampi of mice treated with pilocarpine were examined by quantitative mass spectrometry at 4 and 24 h post-status epilepticus at vast depth. Hundreds of posttranscriptional regulatory proteins were the major early targets of increased phosphorylation. At 24 h, many protein level changes were detected and the phosphoproteome continued to be perturbed. The major targets of decreased p ...[more]