Proteomics

Dataset Information

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Dia-PASEF analysis of human amygdala in Alzheimer’s disease


ABSTRACT: dia-PASEF analysis of human amygdala in Alzheimer’s disease

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Daniel Saiz-Sanchez  

LAB HEAD: Alino Martinez-Marcos

PROVIDER: PXD038322 | Pride | 2023-06-28

REPOSITORIES: Pride

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Publications

Human amygdala involvement in Alzheimer's disease revealed by stereological and dia-PASEF analysis.

Gonzalez-Rodriguez Melania M   Villar-Conde Sandra S   Astillero-Lopez Veronica V   Villanueva-Anguita Patricia P   Ubeda-Banon Isabel I   Flores-Cuadrado Alicia A   Martinez-Marcos Alino A   Saiz-Sanchez Daniel D  

Brain pathology (Zurich, Switzerland) 20230618 5


Alzheimer's disease (AD) is characterized by the accumulation of pathological amyloid-β (Aβ) and Tau proteins. According to the prion-like hypothesis, both proteins can seed and disseminate through brain regions through neural connections and glial cells. The amygdaloid complex (AC) is involved early in the disease, and its widespread connections with other brain regions indicate that it is a hub for propagating pathology. To characterize changes in the AC as well as the involvement of neuronal  ...[more]

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