Dataset Information

Elevated PAF1-RAD52 Axis Confers Chemoresistance to Human Cancers

ABSTRACT: To identify a common protein that interacts with PAF1 in ovarian cancer, lung Cancer, and pancreatic cancer to mediate chemoresistance.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Lung Cancer,Pancreatic Cancer,Malignant Neoplasm Of Ovary

SUBMITTER: Moorthy Ponnusamy

LAB HEAD: Moorthy P. Ponnusamy

PROVIDER: PXD039281 | Pride | 2024-01-26

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	10Jan19_Sanchita_A2780CIS.raw__F002607_.dta	Raw
	10Jan19_Sanchita_A2780PAR.raw__F002609_.dta	Raw
	10Jan19_Sanchita_A549CIS.raw__F002604_.dta	Raw
	10Jan19_Sanchita_A549PAR.raw__F002606_.dta	Raw
	30Jan20_MiaPaca2_GemR.raw__F002640_.dta	Raw

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Publications

Elevated PAF1-RAD52 axis confers chemoresistance to human cancers.

Rauth Sanchita S Ganguly Koelina K Atri Pranita P Parte Seema S Nimmakayala Rama Krishna RK Varadharaj Venkatesh V Nallasamy Palanisamy P Vengoji Raghupathy R Ogunleye Ayoola O AO Lakshmanan Imayavaramban I Chirravuri Ramakanth R Bessho Mika M Cox Jesse L JL Foster Jason M JM Talmon Geoffrey A GA Bessho Tadayoshi T Ganti Apar Kishor AK Batra Surinder K SK Ponnusamy Moorthy P MP

Cell reports 20230128 2

Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common driver of cisplatin and gemcitabine resistance in human cancers (ovarian, lung, and pancreas). Mechanistically, cisplatin- and gemcitabine-resistant cells show enhanced DNA repair, which is inhibited by PAF1 silencing. We demonstrate an increased interaction ...[more]

PMID: 36709426

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