Dataset Information

Identification of the DNALI1 interactome from mouse testis to identify its role in spermatogenesis

ABSTRACT: DNALI1 was immunoprecipitated from mouse testis to identify the interactome of this protein for further functional studies.

INSTRUMENT(S): LTQ Orbitrap, Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis

SUBMITTER: Rong Hua

LAB HEAD: Rong Hua

PROVIDER: PXD039300 | Pride | 2023-03-11

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	injel_AHMU_dnali1_20220211_MAXQUANT.rar	Other
	injel_AHMU_ko_dnalil_20220211.raw	Raw
	injel_AHMU_wt_20220211.raw	Raw

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Publications

DNALI1 deficiency causes male infertility with severe asthenozoospermia in humans and mice by disrupting the assembly of the flagellar inner dynein arms and fibrous sheath.

Wu Huan H Liu Yiyuan Y Li Yuqian Y Li Kuokuo K Xu Chuan C Gao Yang Y Lv Mingrong M Guo Rui R Xu Yuping Y Zhou Ping P Wei Zhaolian Z Hua Rong R He Xiaojin X Cao Yunxia Y

Cell death & disease 20230215 2

The axonemal dynein arms (outer (ODA) and inner dynein arms (IDAs)) are multiprotein structures organized by light, intermediate, light intermediate (LIC), and heavy chain proteins. They hydrolyze ATP to promote ciliary and flagellar movement. Till now, a variety of dynein protein deficiencies have been linked with asthenospermia (ASZ), highlighting the significance of these structures in human sperm motility. Herein, we detected bi-allelic DNALI1 mutations [c.663_666del (p.Glu221fs)], in an ASZ ...[more]

PMID: 36792588

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