Proteomics

Dataset Information

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HTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration

ABSTRACT: We have developed a web-based platform for HTT PPI visualization, exploration, and multi-omic integration called HTT-OMNI. We demonstrate the utility of this platform not only for exploring and filtering existing huntingtin (HTT) PPIs, but also for investigating user-generated omics datasets. For example, we demonstrate the comparison of a published HTT IP-MS experiment, performed in the striatum brain region of a mouse HD model, to unpublished HTT IP-MS experiments in the cortex brain region. Overall, HTT-OMNI summarizes and integrates known HTT PPIs with polyQ-dependent transcriptome and proteome measurements, providing an all-in-one exploratory platform that facilitates the prioritization of target genes that may contribute to HD pathogenesis.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Todd Greco  

LAB HEAD: Ileana M Cristea

PROVIDER: PXD034158 | Pride | 2022-08-15

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
2017_07_UniprotS_mouse.fasta Fasta
2018_11_UniProtS_Mouse.fasta Fasta
20210806_2M-140Q-FLAG_F.msf Msf
20210806_2M-140Q-FLAG_F1.raw Raw
20210806_2M-140Q-FLAG_F2.raw Raw
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HTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration.

Kennedy Michelle A MA   Greco Todd M TM   Song Bokai B   Cristea Ileana M IM  

Molecular & cellular proteomics : MCP 20220803 10

Huntington's disease (HD) is a progressive neurological disorder that is caused by polyglutamine expansion of the huntingtin (HTT) protein. With the hope to uncover key modifiers of disease, a focus of the field of HD research has been on characterizing HTT-interacting proteins (HIPs) and the effect of the HTT polyglutamine expansion on the cellular omics landscape. However, while hundreds of studies have uncovered over 3000 potential HIPs to date, a means to interrogate these complementary inte  ...[more]

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