Dataset Information
APEX1 alters the phospho-landscape of SKOV3 cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Malignant Neoplasm Of Ovary
SUBMITTER: 
Shuyu Mao
LAB HEAD: Yuejin Hua
PROVIDER: PXD040041 | Pride | 2024-05-22
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20220310_KD_1.pep.xml | Pepxml | |||
| 20220310_KD_1.raw | Raw | |||
| 20220310_KD_2.raw | Raw | |||
| 20220310_KD_3.raw | Raw | |||
| 20220310_KD_4.raw | Raw |
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Publications
Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer.
Cellular and molecular life sciences : CMLS 20240304 1
APE1 is an essential gene involved in DNA damage repair, the redox regulation of transcriptional factors (TFs) and RNA processing. APE1 overexpression is common in cancers and correlates with poor patient survival. Stress granules (SGs) are phase-separated cytoplasmic assemblies that cells form in response to environmental stresses. Precise regulation of SGs is pivotal to cell survival, whereas their dysregulation is increasingly linked to diseases. Whether APE1 engages in modulating SG dynamics ...[more]
