Dataset Information

Polyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury

ABSTRACT: Humidifier disinfectant (HD)-associated lung injury (HDLI) not only associates with increased acute morbidity and mortality, but also affects long term lung function due to lung fibrosis. However, there have been no validated marker capable of detecting exposure to HDs or severity of HDLI. This study aims to discover the differential abundant plasma proteome between them and develop prediction score platform using plasma proteome data from HD-exposed patients in order to classify the severity of HDLI. A total of 483 samples were used in this study. The samples used were 162 children in the normal group, 76 in the 4th stage, 51 in the 3rd stage, 54 in the 2nd stage, 42 in the 1st stage and 50 female adults in the normal group, 20 in the 4th stage, 7 in the 3rd stage, 6 in the 2nd stage, and 14 in 1st stage. The lower the grade, the greater the severity of HDLI.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Hee-Sung Ahn

LAB HEAD: Kyunggon Kim

PROVIDER: PXD040122 | Pride | 2024-08-14

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	200708-EH_S001_SWATH_8ul_37m_r01.wiff	Wiff
	200708-EH_S001_SWATH_8ul_37m_r01.wiff.scan	Wiff
	200708-EH_S002_SWATH_8ul_37m_r01.wiff	Wiff
	200708-EH_S002_SWATH_8ul_37m_r01.wiff.scan	Wiff
	200708-EH_S003_SWATH_8ul_37m_r01.wiff	Wiff

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Polyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury.

Ahn Hee-Sung HS Lee So-Yeon SY Kang Mi-Jin MJ Hong Sang Bum SB Song Jin Woo JW Do Kyung Hyun KH Yeom Jeounghun J Yu Jiyoung J Oh Yumi Y Hong Jeong Yeon JY Chung Eun Hee EH Kim Kyunggon K Hong Soo-Jong SJ

Journal of hazardous materials 20240727

Polyhexamethylene guanidine (PHMG) is a positively charged polymer used as a disinfectant that kills microbes but can cause pulmonary fibrosis if inhaled. After the long-term risks were confirmed in South Korea, it became crucial to measure toxicity through diverse surrogate biomarkers, not only proteins, especially after these hazardous chemicals had cleared from the body. These biomarkers, identified by their biological functions rather than simple numerical calculations, effectively explained ...[more]

PMID: 39126856

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