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Whole cell proteome of U-2 OS cells with NPM1 and NPM1c overexpression

ABSTRACT: The nucleolar scaffold protein NPM1 acts as a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants that promote its aberrant cytoplasmic localization, are the most frequent genetic alterations in acute myeloid leukemia (AML). A hallmark of AML cells is their dependency on elevated autophagic flux. In order to identify the proteome changes upon NPM1 and NPM1c overexpression, we performed TMT-labeled mass spectrometry analysis of whole cell lysates.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Stefan Müller

LAB HEAD: Srefan Müller

PROVIDER: PXD040193 | Pride | 2023-11-20

REPOSITORIES: Pride

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			Action	DRS
	20220717_LU_LC2_GT_HM_E428_400ng_F.pdResult.xlsx	Xlsx
	20220717_LU_LC2_GT_HM_E428_400ng_F01.raw	Raw
	20220717_LU_LC2_GT_HM_E428_400ng_F02.raw	Raw
	20220717_LU_LC2_GT_HM_E428_400ng_F03.raw	Raw
	20220717_LU_LC2_GT_HM_E428_400ng_F04.raw	Raw

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