Proteomics

Dataset Information

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Whole cell proteome of OCI-AML3 FKBP12(F36V) cells with dTAG-13 treatment


ABSTRACT: The nucleolar scaffold protein NPM1 acts as a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants that promote its aberrant cytoplasmic localization, are the most frequent genetic alterations in acute myeloid leukemia (AML). A hallmark of AML cells is their dependency on elevated autophagic flux. In order to identify the proteome changes upon NPM1 and NPM1c overexpression, we performed TMT-labeled mass spectrometry analysis of whole cell lysates.

INSTRUMENT(S): Orbitrap Exploris 240

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Leukocyte, Cell Culture

DISEASE(S): Acute Leukemia

SUBMITTER: Stefan Müller  

LAB HEAD: Stefan Müller

PROVIDER: PXD045357 | Pride | 2023-10-28

REPOSITORIES: Pride

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