Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Haonan Li
LAB HEAD: Caigang Liu
PROVIDER: PXD040200 | Pride | 2023-04-12
REPOSITORIES: Pride
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BPI_19596_human_B.msf | Msf | |||
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BPI_19596_human_C.msf | Msf | |||
BPI_19596_human_C.raw | Raw |
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Nature communications 20230505 1
Failure to achieve complete elimination of triple negative breast cancer (TNBC) stem cells after adjuvant therapy is associated with poor outcomes. Aldehyde dehydrogenase 1 (ALDH1) is a marker of breast cancer stem cells (BCSCs), and its enzymatic activity regulates tumor stemness. Identifying upstream targets to control ALDH<sup>+</sup> cells may facilitate TNBC tumor suppression. Here, we show that KK-LC-1 determines the stemness of TNBC ALDH<sup>+</sup> cells via binding with FAT1 and subsequ ...[more]