Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Lukas Beumers
LAB HEAD: Prof. Dr. Stefan Wiemann
PROVIDER: PXD040478 | Pride | 2024-01-26
REPOSITORIES: Pride
Beumers Lukas L Vlachavas Efstathios-Iason EI Borgoni Simone S Schwarzmüller Luisa L Penso-Dolfin Luca L Michels Birgitta E BE Sofyali Emre E Burmester Sara S Heiss Daniela D Wilhelm Heike H Yarden Yosef Y Helm Dominic D Will Rainer R Goncalves Angela A Wiemann Stefan S
NPJ breast cancer 20231202 1
Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this end, we established barcoded models of luminal breast cancer and rendered them resistant to commonly applied first line endocrine therapies. By isolating single clones from the resistant cell pools and characterizing replicates of individual clones we observe ...[more]