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Longitudinal plasma profiling on AML patients

ABSTRACT: Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer, with poor prognosis and wide-raging complications. Early identification and prediction of complications is vital for effective disease management. We performed longitudinal plasma profiling of 26 AML patients during chemotherapy-induced neutropenia, to explore the role of plasma proteins in evaluating the severity and prognosis of AML. We found that the majority of proteins varied in levels between patients, while remaining relatively stable within patients. Inflammatory proteins were significantly correlated with fever and its complications, and may serve as a useful biomarker panel to monitor AML patients during disease progression.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood Plasma

DISEASE(S): Acute Leukemia

SUBMITTER: iris Kreft

LAB HEAD: maartje van den biggelaar

PROVIDER: PXD040526 | Pride | 2024-11-06

REPOSITORIES: Pride

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			Action	DRS
	BIOM002_1.raw	Raw
	BIOM002_2.raw	Raw
	BIOM002_3.raw	Raw
	BIOM002_4.raw	Raw
	BIOM003_1.raw	Raw

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