Longitudinal plasma profiling on AML patients
Ontology highlight
ABSTRACT: Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer, with poor prognosis and wide-raging complications. Early identification and prediction of complications is vital for effective disease management. We performed longitudinal plasma profiling of 26 AML patients during chemotherapy-induced neutropenia, to explore the role of plasma proteins in evaluating the severity and prognosis of AML. We found that the majority of proteins varied in levels between patients, while remaining relatively stable within patients. Inflammatory proteins were significantly correlated with fever and its complications, and may serve as a useful biomarker panel to monitor AML patients during disease progression.
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Blood Plasma
DISEASE(S): Acute Leukemia
SUBMITTER: iris Kreft
LAB HEAD: maartje van den biggelaar
PROVIDER: PXD040526 | Pride | 2024-11-06
REPOSITORIES: Pride
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