Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Yisang Yoon
LAB HEAD: Yisang Yoon
PROVIDER: PXD040556 | Pride | 2023-10-30
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Cyto_Cre_r1.msf | Msf | |||
Cyto_Cre_r1.raw | Raw | |||
Cyto_Cre_r2.msf | Msf | |||
Cyto_Cre_r2.raw | Raw | |||
Cyto_Cre_r3.msf | Msf |
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Lee Hakjoo H Lee Tae Jin TJ Galloway Chad A CA Zhi Wenbo W Xiao Wei W de Mesy Bentley Karen L KL Sharma Ashok A Teng Yong Y Sesaki Hiromi H Yoon Yisang Y
Nature communications 20231023 1
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping. Disruption of OPA1 causes mitochondrial dysfunction. However, the role of OPA1 in liver function is poorly understood. In this study, we delete OPA1 in the fully developed liver of male mice. Unexpectedly, OPA1 liver knockout (LKO) mice are healthy with unaffected mitochondrial respirat ...[more]