Dataset Information

Identifying Targets of Pyrvinium Pamoate in Jurkat Cells using PISA

ABSTRACT: Pyrvinium pamoate, an anthelmintic drug, inhibits mitochondrial biogenesis during initial T-cell activation; however, its molecular target(s) and mechanism of action are unknown. In this study, we treated Jurkat T cell lysate with pyrvinium pamoate (5 nM and 50μM) and used proteome integral solubility alteration (PISA), to identify potential targets.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Jurkat Cell

SUBMITTER: Brandon Gassaway

LAB HEAD: Steven Gygi

PROVIDER: PXD040663 | Pride | 2023-08-29

REPOSITORIES: Pride

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			Action	DRS
	561644_a27444_PP_PISA.mzIdentML	Mzid
	561645_a27443_PP_PISA.mzIdentML	Mzid
	561646_a27442_PP_PISA.mzIdentML	Mzid
	561647_a27441_PP_PISA.mzIdentML	Mzid
	561648_a27440_PP_PISA.mzIdentML	Mzid

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Identifying Targets of Pyrvinium Pamoate in Jurkat Cells using PISA

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