Proteomics

Dataset Information

0

The mouse aging proteomic atlas

ABSTRACT: This database provides TMT-labeled proteomic data of aorta (thoracic aorta), brain, heart, kidney, liver, lung, muscle (gastrocnemius muscle), and skin (abdominal skin) of 6, 15, 24, and 30 months old male C57BL/6 mice. In addition to the whole-tissue lysate, low-soluble protein-enriched fraction was also analyzed for heart, kidney, lung, muscle, and skin. Bulk RNA-Seq data are available for brain, heart, kidney, liver, lung, muscle, and skin. The tissues used for transcriptomic analysis and proteomic analysis of whole-tissue lysate and low-soluble protein-enriched fraction were collected from the same mice. All analyses were conducted with 4 biological replicates.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Lung, Skin, Kidney

SUBMITTER: Frank Stein  

LAB HEAD: Naoko Ohtani

PROVIDER: PXD040722 | Pride | 2024-09-17

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
Aorta_merged_results_20220531_0009_peptides.txt Txt
Aorta_merged_results_20220531_0009_proteins.txt Txt
Aorta_merged_results_20220531_0009_summary.txt Txt
F114961.dat Other
F114962.dat Other
Items per page:
1 - 5 of 400
altmetric image

Publications

An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation.

Takasugi Masaki M   Nonaka Yoshiki Y   Takemura Kazuaki K   Yoshida Yuya Y   Stein Frank F   Schwarz Jennifer J JJ   Adachi Jun J   Satoh Junko J   Ito Shinji S   Tombline Gregory G   Biashad Seyed Ali SA   Seluanov Andrei A   Gorbunova Vera V   Ohtani Naoko N  

Nature communications 20241002 1

To what extent and how post-transcriptional dysregulation affects aging proteome remains unclear. Here, we provide proteomic data of whole-tissue lysates (WTL) and low-solubility protein-enriched fractions (LSF) of major tissues collected from mice of 6, 15, 24, and 30 months of age. Low-solubility proteins are preferentially affected by age and the analysis of LSF doubles the number of proteins identified to be differentially expressed with age. Simultaneous analysis of proteome and transcripto  ...[more]

Similar Datasets

Proteomics Identification of proteins that form complexes with SerpinA1 by LC-MS/MS
2024-10-01 | PXD056002 | Pride
Transcriptomics Prostates of rats with induced partial bladder outlet obstruction and the effect of Eviprostat on those changes
2010-04-09 | E-GEOD-16063 | biostudies-arrayexpress
Transcriptomics Taurine transporter (SLC6A6)-deficient skeletal muscle
2014-05-08 | E-GEOD-57373 | biostudies-arrayexpress
Transcriptomics Plasma miRNA Expression Profiling Using Human TaqMan Low Density Array Cards
2013-04-13 | E-GEOD-46012 | biostudies-arrayexpress
Transcriptomics Comparision of expression profile between wild-type and Slc39a13 knockout osteoblasts
2008-11-07 | E-GEOD-10555 | biostudies-arrayexpress
Transcriptomics Transcription profiling of human H1299 cells and Saos-2 cells (p53 null cells) transfected with Flag vector, Flag-p53 WT or Flag-p53 SA
2010-10-14 | E-MEXP-2556 | biostudies-arrayexpress
Transcriptomics RNAi profiling by array of human U2-OS cells transfected with PKC delta siRNA and then left untreated or treated with adriamycin
2011-03-23 | E-MEXP-2643 | biostudies-arrayexpress
Transcriptomics HuSE2,2Dvs3D
2013-12-10 | E-MTAB-1491 | biostudies-arrayexpress
Transcriptomics Comparison of gene expression between wild-type and PTIP deficient chicken DT40 B cells
2009-10-27 | E-GEOD-18778 | biostudies-arrayexpress
Transcriptomics The gene expression profiles of WT and NML-KO livers
2013-06-22 | E-GEOD-48191 | biostudies-arrayexpress