Ontology highlight
ABSTRACT:
ORGANISM(S): Gallus gallus
SUBMITTER: XIN WANG
PROVIDER: E-GEOD-18778 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Xin X Takenaka Katsuya K Takeda Shunichi S
Genes to cells : devoted to molecular & cellular mechanisms 20100119 3
PTIP (Pax2 transactivation domain-interacting protein) is a large nuclear protein containing six BRCT (BRCA1 C-Terminal) domains. PTIP is recruited to DNA-damage sites through its BRCT domains and thus has been implicated in the DNA damage response. To define the function of PTIP in DNA repair, we disrupted the PTIP gene of the chicken DT40 B cell line. PTIP mutant (PTIP(-/-/-) ) cells displayed phenotypes frequently observed in cells with defective homologous recombination (HR), i.e. a marked i ...[more]