Proteomics

Dataset Information

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Temporal proteomic profiling reveals functional pathways in vaccinia-induced cell migration


ABSTRACT: Viral diseases have alwanys been intricate and persistent issues throughout the world and lack of holistic discoveries of molecular dysregulations of virus-host interactions. The temporal proteomics strategy can identify various differentially expressed proteins and offer collaborated interaction networks under pathological conditions. Herein, temporal proteomics at various hours post infection of Vero cells were launched to uncover molecular alternations during vaccinia virus-induced cell migration. Different stages of infection were included to differentiate gene ontologies and critical pathways at specific time points of infection. The enrichment of functional interaction networks and pathways verified the significances of regulation of actin cytoskeleton and lamellipodia during vaccinia virus-induced fast cell motility. Current results offer the systematic proteomic profiling og molecular dysregulations at different stages of vaccinia virus infection and potential biomedical targets for treating viral diseases.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Chlorocebus Sabaeus

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Disease Free

SUBMITTER: Jiayin Lu  

LAB HEAD: Jiayin Lu

PROVIDER: PXD040845 | Pride | 2023-05-04

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
12h_1.raw Raw
12h_2.raw Raw
12h_3.raw Raw
20210626_110047_YS-436-20210626.sne Other
24h_1.raw Raw
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