Dataset Information

Identification and functional characterization of NCoR1-interacting proteins associated with mitochondrial biogenesis

ABSTRACT: This study was designed to identify putative NCoR1-interacting proteins that might regulate the mitochondrial biogenesis process. To do that, MEF cells were transiently transfected with plasmid expressing either pcDNA-GFP-FLAG (control) or pCMX-NCoR1-FLAG and subjected to co-IP and identification of interacting proteins by liquid chromatography tandem mass spectrometry (LC-MS/MS) (LTQ Velos Orbitrap).

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Fibroblast

SUBMITTER: Adriana Franco Paes Leme

LAB HEAD: Leonardo Silveira

PROVIDER: PXD040945 | Pride | 2023-07-20

REPOSITORIES: Pride

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Publications

Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response.

Oliveira A G AG Oliveira L D LD Cruz M V MV Guimarães D S P S F DSPSF Lima T I TI Santos-Fávero B C BC Luchessi A D AD Pauletti B A BA Leme A P AP Bajgelman M C MC Afonso J J Regitano L C A LCA Carvalho H F HF Carneiro E M EM Kobarg J J Perissi V V Auwerx J J Silveira L R LR

The Journal of biological chemistry 20230412 6

Mitochondria are organelles known primarily for generating ATP via the oxidative phosphorylation process. Environmental signals are sensed by whole organisms or cells and markedly affect this process, leading to alterations in gene transcription and, consequently, changes in mitochondrial function and biogenesis. The expression of mitochondrial genes is finely regulated by nuclear transcription factors, including nuclear receptors and their coregulators. Among the best-known coregulators is the ...[more]

PMID: 37059182

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	05dez_Andre_NCor_1.raw	Raw
	05dez_Andre_NCor_2.raw	Raw
	05dez_Andre_NCor_3.raw	Raw
	05dez_Andre_pCDNA_1.raw	Raw
	05dez_Andre_pCDNA_2.raw	Raw