Proteomics

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INTERACTOME ANALYSIS IDENTIFIES THE ROLE OF BZW2 IN PROMOTING ENDOPLASMIC RETICULUM-MITOCHONDRIAL CONTACT AND MITOCHONDRIAL METABOLISM

ABSTRACT: Maio et. al. presents a comprehensive and quantitative interactome of BZW2, a protein found to promote human cancers with little known about its molecular function. Many of the proteins identified were either mitochondrial or endoplasmic reticulum (ER) proteins, suggesting BZW2 may play a role in mitochondria-ER contact. We found that BZW2 indeed localizes to and promotes the formation of mitochondria-ER contact sites (MERCS), thus promoting calcium transport from ER to the mitochondria and promotes mitochondrial ATP production. These findings provide key insights into molecular functions of BZW2, the potential role of BZW2 in cancer progression, and highlights the utility of interactome data in understanding the function of less-studied proteins.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Sheng Zhang  

LAB HEAD: Sheng Zhang

PROVIDER: PXD041354 | Pride | 2024-05-24

REPOSITORIES: Pride

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Action DRS
F1.mgf Mgf
F1.msf Msf
F2.mgf Mgf
F2.msf Msf
GeorgeMaio10426101_BZW2-Foward_1.raw Raw
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Publications

Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism.

Maio George G   Smith Mike M   Bhawal Ruchika R   Zhang Sheng S   Baskin Jeremy M JM   Li Jenny J   Lin Hening H  

Molecular & cellular proteomics : MCP 20231226 2

Understanding the molecular functions of less-studied proteins is an important task of life science research. Despite reports of basic leucine zipper and W2 domain-containing protein 2 (BZW2) promoting cancer progression first emerging in 2017, little is known about its molecular function. Using a quantitative proteomic approach to identify its interacting proteins, we found that BZW2 interacts with both endoplasmic reticulum (ER) and mitochondrial proteins. We thus hypothesized that BZW2 locali  ...[more]

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