Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture
SUBMITTER: Thomas Mair
LAB HEAD: Stefan G Lechner
PROVIDER: PXD041372 | Pride | 2023-07-20
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
230303_PIEZO2_Pure_Kit.msf | Msf | |||
230303_PIEZO_Kit_8B1.raw | Raw | |||
230303_PIEZO_Kit_GFKT.raw | Raw | |||
230303_PIEZO_Pure_8B1_20230313193220.raw | Raw | |||
230303_PIEZO_Pure_GFKT_20230313174158.raw | Raw |
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The Journal of biological chemistry 20230504 6
PKA is a downstream effector of many inflammatory mediators that induce pain hypersensitivity by increasing the mechanosensitivity of nociceptive sensory afferent. Here, we examine the molecular mechanism underlying PKA-dependent modulation of the mechanically activated ion channel PIEZO2, which confers mechanosensitivity to many nociceptors. Using phosphorylation site prediction algorithms, we identified multiple putative and highly conserved PKA phosphorylation sites located on intracellular i ...[more]