Dataset Information

Profiling of purified autophagic vesicle content and degradome in the maturing and aging brain - Part II

ABSTRACT: In this second part of the project “Profiling of purified autophagic vesicle content and degradome in the maturing and aging brain” four label-free proteomics studies were performed to characterize stabilization of potential autophagy targets upon lysosomal and/or autophagy inhibition.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Joern Dengjel

LAB HEAD: Joern Dengjel

PROVIDER: PXD041376 | Pride | 2023-08-07

REPOSITORIES: Pride

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			Action	DRS
	20221230_DS_Col99E_emma_BaF_R1_7.raw	Raw
	20221230_DS_Col99E_emma_BaF_R3_9.raw	Raw
	20221230_DS_Col99E_emma_BaF_R4_10.raw	Raw
	20221230_DS_Col99E_emma_BaF_R5_11.raw	Raw
	20221230_DS_Col99E_emma_BaF_R6_12.raw	Raw

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Publications

Profiling of purified autophagic vesicle degradome in the maturing and aging brain.

Kallergi Emmanouela E Siva Sankar Devanarayanan D Matera Alessandro A Kolaxi Angeliki A Paolicelli Rosa Chiara RC Dengjel Joern J Nikoletopoulou Vassiliki V

Neuron 20230605 15

Autophagy disorders prominently affect the brain, entailing neurodevelopmental and neurodegenerative phenotypes in adolescence or aging, respectively. Synaptic and behavioral deficits are largely recapitulated in mouse models with ablation of autophagy genes in brain cells. Yet, the nature and temporal dynamics of brain autophagic substrates remain insufficiently characterized. Here, we immunopurified LC3-positive autophagic vesicles (LC3-pAVs) from the mouse brain and proteomically profiled the ...[more]

PMID: 37279748

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