Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro 2
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Eric Fischer
LAB HEAD: Eric Fischer
PROVIDER: PXD041595 | Pride | 2023-05-14
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 22 |
Monda Julie K JK Ge Xuezhen X Hunkeler Moritz M Donovan Katherine A KA Ma Michelle W MW Jin Cyrus Y CY Leonard Marilyn M Fischer Eric S ES Bennett Eric J EJ
Cell reports 20230509 5
HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 engages its structurally diverse substrates and how HUWE1 activity is regulated are unknown. Using unbiased quantitative proteomics, we find that HUWE1 targets substrates in a largely cell-type-specific manner. However, we identify C16orf72/HAPSTR1 as a robust HUWE1 substrate in multiple cell lines. Previously established physi ...[more]